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Spermidine, derived from wheat germ belongs to a class of molecules called polyamines which are important for cell growth, cell repair, maintenance of transport channels called ion channels, and inducing autophagy or cellular cleanup. Like NAD+,  polyamine levels decrease with age. Supplementing with spermidine has been shown to have healthy aging effects, by improving the health of cells and prolonging their lifespan. 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Conventional “lipoic acid” supplements are only 50% R - lipoic acid; the other half of such supplements is the artificial S - enantiomer. Research demonstrates that R -lipoic acid is more potent that the S -form, and that in some cases the S -form interferes with R - lipoic acid’s actions in the body. 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