Renew Life BoulardiiMAX - Saccharomyces boulardii has been isolated from the skins of tropical fruits found in Indochina. The indigenous population of Indochina has long used these fruit skins to prevent and treat diarrhea. Many quality human research studies have also indicated that Saccharomyces boulardii can be effective in preventing antibiotic-associated diarrhea, diarrhea caused by Clostridium difficile, as well as diarrhea caused by other types of bacteria.